mid-14c., "a consideration; a judgment," from Old French regard, from regarder "take notice of," from re-, intensive prefix + garder "look, heed," from Germanic (see guard (n.)). Meanings "a look, appearance; respect, esteem, favor, kindly feeling which springs from a consideration of estimable qualities" all recorded late 14c. Phrase in regard to is from mid-15c. (Chaucer uses at regard of).