1650s, "without meaning," also "answering to no purpose," from in- (1) "not, opposite of" + significant. From 1748 as "small in size." Related: Insignificantly.
insignificant sounds
a minor, insignificant bureaucrat
an insignificant sum of money
insidious
insight
insightful
insignia
insignificance
insignificant
insincere
insincerity
insinuate
insinuating
insinuation