1590s, of a river, etc., "pour out or discharge at the mouth" (transitive); c. 1600, "flow out, become discharged" (intransitive), from Spanish disembocar, from dis- "opposite of" (see dis-) + embocar "enter by the mouth or by a narrow passage," from boca "mouth" (see bouche).
disease
diseased
disembark
disembodied
disembody
disembogue
disembowel
disempower
disenchant
disenchantment
disencumber