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The Merck Manual--Second Home Edition logo
 
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Chapter 264. Problems in Newborns
Topics: Introduction | Birth Injury | Prematurity | Postmaturity | Small for Gestational Age | Large for Gestational Age | Respiratory Distress Syndrome | Transient Tachypnea | Meconium Aspiration Syndrome | Persistent Pulmonary Hypertension | Pneumothorax | Bronchopulmonary Dysplasia | Apnea of Prematurity | Retinopathy of Prematurity | Necrotizing Enterocolitis | Hyperbilirubinemia | Anemia | Polycythemia | Disorders of the Thyroid Gland | Neonatal Sepsis
 
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Small for Gestational Age

A newborn, whether delivered preterm, term, or postterm, whose weight is less than that of 90% of babies of the same gestational age at birth (below the 10th percentile) is considered small for gestational age.

There are several causes for this condition. In many cases, the newborn may be small simply because of genetic factors, such as having small parents (less commonly, a specific genetic syndrome associated with small stature may be involved). In other cases, the placenta may have functioned poorly, so that the fetus did not receive adequate nutrients and growth was impaired. This may happen if the mother has high blood pressure, preeclampsia, kidney disease, or long-standing diabetes. A viral infection, such as cytomegalovirus acquired before birth, may be responsible. Fetal growth may also have been impaired if the mother smoked or used alcohol or illicit drugs during the pregnancy (see Section 22, Chapter 259). Unless they have a genetic syndrome or viral infection, most small-for-gestational-age newborns have no symptoms. If the fetal growth was impaired because of poor placental function and inadequate nutrition, the newborn's growth may accelerate when provided with good nutrition after delivery. Some small-for-gestational-age newborns remain small as children and adults.

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