Effects of Aging

As people age, there is a slow, steady decline in the weight of the kidneys. After about age 30 to 40, about two thirds of people (even those who do not have kidney disease) undergo a gradual decline in the rate at which their kidneys filter blood. However, the rate does not change in the remaining one third of older people, which suggests that factors other than age may affect kidney function.

As people age, many glomeruli are lost because of thickening of the walls, or even blockage, of some of the small arteries that flow into the glomeruli. Accompanying the loss of glomeruli is a decline in the ability of the nephrons to concentrate or dilute urine and to excrete acid. Despite age-related changes, however, sufficient kidney function is preserved to meet the needs of the body. Changes that occur with age do not in and of themselves cause disease, but the changes do reduce the amount of reserve kidney function that is available.

The ureters do not change much with age, but the bladder and the urethra do undergo some changes. The maximum volume of urine that the bladder can hold decreases. A person's ability to delay urination after first sensing a need to urinate also declines. The rate of urine flow out of the bladder and into the urethra slows. Throughout life, sporadic contractions of bladder wall muscles occur separate from any need or appropriate opportunity to urinate. In younger people, most of these contractions are blocked by spinal cord and brain controls, but the number of sporadic contractions that are not blocked rises with age. There is an increase in the amount of urine that remains in the bladder after urination is completed. In women, the urethra shortens and its lining becomes thinner; these changes in the urethra decrease the ability of the urinary sphincter to close tightly. The trigger for these changes in a woman's urethra seems to be a declining level of estrogen during menopause.