c. 1600, oath of surprise or anger, altered from (by) God's wounds!, in reference to the wounds of Christ on the Cross. "One of the innumerable oaths having reference to Christ's passion" [Century Dictionary]. Compare gadzooks.
Zoroastrianism
zorro
zoster
zouave
zouk
zounds
zowie
zucchetto
zucchini
zugzwang
Zulu