20th letter of the Greek alphabet, 1640s, from Greek u psilon, literally "a mere (or bare) 'u;' " so called in later Greek in reference to its sound. The exact reason is variously explained, but it seems to have had something to do with distinguishing it from diphthongs.
upscale
upset
upshot
upside
upside down
upsilon
upskirt
upstage
upstairs
upstanding
upstart