1590s, "mischievous;" 1773 in the sense of "associated with the supernatural," originally Scottish and northern English, from un- (1) "not" + canny. In late 18c. canny itself had a sense of "possessed of supernatural powers, skilled in magic."
his uncanny sense of direction
unbuckle
unburden
unburied
unbutton
uncalled
uncanny
uncap
uncaring
unceasing
uncensored
unceremonious