1977, earlier retravirus (1974), from re(verse) tra(nscriptase) + virus. So called because it contains reverse transcriptase, an enzyme that uses RNA instead of DNA to encode genetic information, which reverses the usual pattern. Remodeled by influence of retro- "backwards."
retrospect
retrospection
retrospective
retrousse
retroversion
retrovirus
retune
return
returnable
Reuben
*reudh-