"airplane flight which deprives travelers of sleep," 1968, from the red eyes of sleeplessness; earlier as a noun meaning "raw and inferior whiskey" (1819, American English).
The candidate red-eyed from California to the East Coast the night before the election to give a last stump speech
Redemptorist
redeploy
redeployment
redesign
redevelopment
red-eye
redfish
red-handed
redhead
red-hot
redial