1670s, "principal character in a story, drama, etc.," from Greek prÅtagÅnistÄ“s "actor who plays the chief or first part," from prÅtos "first" (from PIE root *per- (1) "forward," hence "in front of, first, chief") + agÅnistÄ“s "actor, competitor," from agÅn "contest" (from PIE root *ag- "to drive, draw out or forth, move"). Meaning "leading person in any cause or contest" is from 1889. Mistaken sense of "advocate, supporter" (1935) is from misreading of Greek prÅtos as Latin pro- "for." Compare antagonist. Deuteragonist "second person or actor in a drama" is from 1840.