c. 1300, pocioun "medicinal drink, dose of liquid medicine or poison," from Old French pocion "potion, draught, medicine" (12c.), from Latin potionem (nominative potio) "a potion, a drinking," also "poisonous draught, magic potion" (source also of Spanish pocion "potion," ponzoña "poison," Italian pozione "potion"), from potus, irregular past participle of potare "to drink," from PIE root *po(i)- "to drink." A doublet of poison (n.). By early 15c. specifically as a magical or enchanted drink.