1540s, a medical word for "excess of body fluid, overfullness of blood," from Late Latin plethora, from Greek plēthōrē "fullness," from plēthein "be full" (from PIE root *pele- (1) "to fill"). Figurative meaning "too-muchness, overfullness" in any respect is recorded by 1700. Related: Plethoric.
pleo-
pleomorphic
pleonasm
pleonastic
plesiosaurus
plethora
*pleu-
pleura
pleural
pleurisy
pleuro-