1550s (in imprecations, "a pest upon ____," etc.), "plague, pestilence, epidemic disease," from Middle French peste (1530s), from Latin pestis "deadly contagious disease; a curse, bane," a word of uncertain origin. Meaning "any noxious, destructive, or troublesome person or thing" is attested by c. 1600. Pest-house "hospital for persons suffering from infectious diseases" is from 1610s.
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