"cessation, restraint, relaxation, intermission," 1837, from verbal phrase let up "cease, stop" (1787). In Old English the phrase meant "to put ashore" (let out meant "put to sea"). Bartlett (1848) says the noun is "an expression borrowed from pugilists."
letter-press
letter-rack
letters
letting
lettuce
let-up
*leu-
leu
*leubh-
leucocyte
*leue-