"space between" (any two things), early 15c., from Late Latin interspatium, from inter "between" (see inter-) + spatium (see space (n.)). As a verb, "fill or occupy the space between," 1832. Related: Interspaced; interspacing.
interrupt
interruption
intersect
intersection
intersex
interspace
interspecific
intersperse
interspersion
interstate
interstellar