"chronic inability to sleep," 1620s, insomnie, from Latin insomnia "want of sleep, sleeplessness," from insomnis "sleepless," from in- "not" (see in- (1)) + somnus "sleep" (from PIE root *swep- "to sleep"). The re-Latinized form is from 1758.
insolubility
insoluble
insolvable
insolvency
insolvent
insomnia
insomniac
insomuch
insouciance
insouciant
inspect