1560s, "assail, trouble;" 1590s, "lay or impose as something that must be suffered," from Latin inflictus, past participle of infligere "to strike or dash against; inflict," from in- "in" (from PIE root *en "in") + fligere (past participle flictus) "to dash, strike" (see afflict). You inflict trouble on someone; you afflict someone with trouble. Shame on you.
inflected
inflection
inflexibility
inflexible
inflexion
inflict
infliction
in-flight
inflorescence
inflow
influence