1660s, "empty, void," from Latin inanis or else a back-formation from inanity (q.v.). Sense of "silly, empty-headed" is from 1819. Related: Inanely. Bailey's Dictionary (1731) has inaniloquent "given to empty talk."
inadvisability
inadvisable
inalienable
inamorata
inamorato
inane
inanimate
inanition
inanity
inappetence
inapplicable