1873, "situated on or affecting the dura mater," from epi- "on" + dura mater + -al (1). The noun meaning "injection into the epidural region" (usually given during childbirth) is attested by 1966.
epidemic
epidemiology
epidemy
epidermis
epididymis
epidural
epigastrium
epiglottis
epigone
epigram
epigrammatic