1620s, "of or pertaining to diagnosis," also as a noun, "a symptom of value in diagnosis," from Greek diagnÅstikos "able to distinguish," from diagnÅstos, verbal adjective from diagignÅskein "to discern, distinguish," literally "to know thoroughly" or "know apart (from another)," from dia "between" (see dia-) + gignÅskein "to learn, to come to know," from PIE root *gno- "to know." Related: Diagnostics.