1905, of substances, "action of depriving of poisonous qualities;" 1971, "removal of addictive substances from the body," originally in reference to habitual heavy drinkers of alcohol; see detoxify + noun ending -ation. As a type of alternative health treatment, by 1997.
detonation
detonator
detour
detox
detoxicate
detoxification
detoxify
detract
detraction
detractor
detriment