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debilitative (adj.)

"tending to render weak or infirm," 1680s, with -ive + Latin debilitat-, stem of debilis "lame, disabled, crippled," figuratively "weak, helpless," from de "from, away" (see de-) + -bilis "strength," from PIE root *bel-"strong" (see Bolshevik). 

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Definitions of debilitative from WordNet

debilitative (adj.)
causing debilitation;
Synonyms: enervating / enfeebling / weakening
From wordnet.princeton.edu