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blocker (n.)

c. 1400 of a tool, c. 1600 of a person, agent noun from block (v.1). U.S. football sense from 1914.

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Definitions of blocker from WordNet

blocker (n.)
a football player whose responsibility is to block players attempting to stop an offensive play;
blocker (n.)
a class of drugs that inhibit (block) some biological process;
Synonyms: blocking agent
From wordnet.princeton.edu