"up and about," 1799, Scottish English, from phrase on the stir, or from Scottish asteer; from a- (1) + stir (see stir (v.)). Old English had astyrian, which yielded Middle English ben astired "be stirred up, excited, aroused."
the whole town was astir over the incident
are they astir yet?
asthenosphere
asthma
asthmatic
astigmatic
astigmatism
astir
astonish
astonishing
astonishment
astound
astounding